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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-34a
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples and adjacent noncancerous tissues; RB cell lines HXO-RB44, SO-RB50, Y79 and WERI-RB1
Methods qRT-PCR, luciferase reporter assay, Western blot, apoptosis assay
Expression pattern down-regulated
Functional description The miR‑34a/MAGE‑A/p53 axis may be conducive to enhancing the efficacies of chemotherapeutic treatments for RB.
PubMed ID 30387834
Year 2019
Title miR‑34a regulates the chemosensitivity of retinoblastoma cells via modulation of MAGE‑A/p53 signaling.
Drug-related ncRNA NO

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